Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

习惯行为、执行意向与青少年身体活动意向与行为:基于计划行为理论的扩展模型     

王丽娟  郑丹蘅 《上海体育学院学报》2020,(2):22-32

在计划行为理论(TPB)的基础上,引入身体活动习惯行为与执行意向,构建扩展TPB(METPB)模型,检验该模型对9~19岁青少年群体的中高强度身体活动(MVPA)的适用性,探讨该模型对小学、初中及高中阶段青少年MVPA影响的差异。结果显示:假设模型的拟合度可以接受,纳入习惯行为与执行意向后,METPB显著地提高了其对身体活动行为的解释力。态度和感知行为控制对MVPA行为意向有显著性影响,解释了31.4%的行为意向方差;行为意向和习惯行为对MVPA行为有显著性影响,解释了18.7%的行为方差;执行意向加强了行为意向朝实际行为的转换。METPB模型对于不同学习阶段青少年MVPA意向及行为的影响有显著性差异。其中:主观规范对小学生与初中生MVPA意向产生了显著性影响,而对高中生的MVPA意向并无显著性影响;感知行为控制对3个阶段学生的MVPA意向产生的影响随着学习阶段的上升不断增强。建议:在对于青少年身体活动的干预中,政府、家庭、学校应重视培养学生对于身体活动参与的正确态度,提高其参与身体活动的意愿,培养其参与身体活动的行为习惯,且在对青少年身体活动干预时考虑学习阶段的差异。  相似文献   

上海“体教结合”举措下竞技体育后备人才“学生-运动员”双重角色的认同、冲突与转化          下载免费PDF全文

侯爽 《体育科研》2019,(3):30-37

“体教结合”是解决当前我国竞技体育发展问题的重要途径和举措。传统的体育后备人才培养模式只重视专项体育技能的发展而忽视了文化教育的重要性，不利于个体的全面发展。“体教结合”更重视人的全面发展，体育与教育的融合，使得竞技体育人才逐渐从运动员这一单一角色向“学生-运动员”双重角色转变。研究以角色认同为切入口，探讨上海“体教结合”举措下，角色的转变对体育竞技后备人才的影响。选取上海体育学院中国乒乓球学院少年班学员作为“学生-运动员”样本，选取国家乒乓球青年队及部分省市队队员作为职业运动员样本，使用结构化心理测量工具，对比两类受访者在运动与学业上的角色认同、心理倦怠与动机变量的差异。得出：在上海“体教结合”举措下，竞技体育后备人才认同“学生-运动员”双重角色，他们在学业任务中的卷入程度更高；双重角色使运动员在运动任务与学业任务上的主观价值感存在差异，表现出双重角色之间的冲突，但对个体的整体人生规划并不冲突；双重角色之间的转化，对于“学生-运动员”的心理健康存在促进效应。  相似文献   

知识找回场景下推荐系统模拟实现及评价研究     

程秀峰  张孜铭  孟亚琪  范晓莹  杨金庆 《图书情报工作》2019,63(16):72-83

[目的/意义]信息过载一直是知识工作者在搜集、处理和创造知识的过程中所面临的主要困境。这种困境导致的结果之一是很难回忆起曾经使用过的文档的内容细节及具体位置，而推荐系统则能减少这样的困难。通过研究对比不同推荐系统在这一任务下的优缺点，可以帮助知识工作者更好地完成回忆任务。[方法/过程]基于相关理论，在同一场景（知识找回）模拟实现并测试了4种不同类型的推荐过程，包括基于内容的推荐CBR、基于协同过滤的推荐CFR、基于推理网络的推荐INR与融入了情境感知的推荐CAS，根据所确定的若干指标（精确性、情境相关性、预测性、多样性）对推荐效果进行比较。[结果/结论]结果显示，以上推荐系统在帮助用户回忆并找回文档过程中都有各自的优势，而基于情境感知的推荐系统在情境相关性与预测用户行为方面具有较好的效果。  相似文献   

Nostalgia,homesickness and emotional formation on the eighteenth-century Grand Tour     

Sarah Goldsmith 《Cultural and Social History》2018,15(3):333-360

Nostalgia and homesickness were well-known eighteenth-century ailments. Undertaking protracted travels, Grand Tourists were potential sufferers, yet these emotional afflictions are absent from the Tour's lengthy lists of hazards. Querying this and applying history of emotions approaches to the histories of the Tour, masculinity and the family, this article examines how Tourists and tutors navigated nostalgia and homesickness as emotions that sat uneasily with the Tour's wider aims of masculine formation. Such investigations offer a means of unpicking the complex, contradictory demands placed on young gentlemen during their emotional formation. Through this, it contributes to wider reconsiderations of eighteenth-century masculinity.  相似文献   

The Eton Montem custom c. 1750–1844: privilege,pageantry and sanctioned misrule     

Catherine Dille 《Cultural and Social History》2018,15(3):361-377

Montem, a triennial customary march by Eton scholars, consolidated into a public expression of patrician social identity under the patronage of the monarchy in the late eighteenth century. This analysis of Montem’s history traces its development from a boy-led pageant of misrule to a public performance of elite patriotism. The custom, which attracted national attention, sheds new light on boy governance and self-fashioning in the period’s elite schools. This article argues that a study of Montem disrupts the standard historiographical narrative of anarchy and violence in the great schools and suggests that boy culture was more complex than previously acknowledged.  相似文献   

From objects to subjects: Repositioning teachers as policy actors doing policy work     

《Teaching and Teacher Education》2018

Within policy discourses, teachers are positioned as objects of reform who enact policies under rational systems of observation and accountability and are, therefore, situated as de-professionalized actors lacking expert knowledge. This research project asks relatively straight-forward questions: If practicing teachers were given a voice in political debates over urban education policy and reform, what would they say? What macro-level policy problems would they identify as being important? Findings indicate the primary policy problems include Systemic Inequity and Bad Policy. The primary policy solutions include, Schools as a Community Resource; Shared Decision-Making; Contextual Goals; and Time, Space and Resources.  相似文献   

体育文化交流对中美关系改善的作用及启示——基于中美建交40年的历史考察     

肖焕禹  倪京帅 《武汉体育学院学报》2019,53(10):12-18

运用文献资料等研究方法，基于"契机-轨迹"理论，对中美建交40年来体育文化交流情况进行了回顾和梳理，分析了外交政策导向下中美体育文化交流"契机"的形成和"轨迹"的发展，解读中美建交的历史背景和体育文化交流的特征与价值。认为：在"和平与发展""构建开放合作和谐社会""新时代构建新型国际关系"外交政策的影响下，中美体育文化交流具有体育文化财富的共享性、体育竞技的对等性、体育文化交流的公共性特征；中美体育文化交流促进中美建交，促进中美和平发展；改变世界格局，获得话语权；树立国家形象，展示大国责任；深化体育改革，促进社会发展。  相似文献   

下一代图书馆系统平台的实践与思考     

邵波  张文竹 《图书情报工作》2019,63(1):98-104

[目的/意义]大数据与人工智能等技术为图书馆智慧服务带来机遇与挑战，图书馆新系统平台建设刻不容缓。旨在探讨下一代图书馆系统平台发展现状及对策，为建设一流高校智慧图书馆提供实践案例与参考依据。[方法/过程]梳理图书馆系统平台发展脉络，在盘点现有的国内外下一代图书馆系统平台的研究与实践的基础上，以南京大学为例，探索图书馆新系统平台的建设方案。[结果/结论]智慧图书馆将通过建设一体化电子资源管理平台并打造NLSP，提升图书馆资源管控和知识服务水平，构建开放共享的智慧图书馆服务体系。  相似文献   

Contemporary school knowledge democracy: possible meanings,promising perspectives and necessary prerequisites     

Eleni Katsarou  Konstantinos Sipitanos 《Educational Action Research》2019,27(1):108-124

ABSTRACT

The basic aim of this paper is to discuss the concept ‘Knowledge Democracy’ (KD) and what it can mean in the school context, its implications on knowledge production and dissemination and on the educational practices. We try to enrich this discussion by presenting action research projects to provide case studies of how thinking about KD can reshape educational practice. We consider that the discussion on KD has to be enriched as the concept seems very promising with good prospects towards school’s democratization. On the other hand, as it is quite new, it can encompass internal contradictions that can cause problems at the level of practice. So, we consider very important any contribution to this discussion not as another theoretical sample of the debate on the ‘politics of knowledge’, but because any improvement at the thinking of the issue can be reflected on school practices. Any challenge to traditional politics of knowledge can lead to a deeper understanding of the world of schooling and to transformations through new discourses and new approaches to teaching and learning in school.  相似文献